RAPID COMMUNICATION Fas-Mediated Apoptosis of CD4+ and CD8+ T Cells From Human Immunodeficiency Virus-Infected Persons: Differential In Vitro Preventive Effect of Cytokines and Protease Antagonists

نویسندگان

  • JBrBme Estaquier
  • Masato Tanaka
  • Takashi Suda
  • Shigekazu Nagata
  • Pierre Golstein
  • Jean Claude Ameisen
چکیده

Human immunodeficiency syndrome (HIV) infection leads to a progressive loss of T-cell-mediated immunity associated with T-cell apoptosis. We report here that CD4’ and CD8’ T cells from HIV-l-infected persons are sensitive to Fas (CD95/APO-l)-mediated death induced either by an agonistic anti-Fas antibody or by the physiologic soluble Fas ligand, although showing no sensitivity to tumor necrosis factor ainduced death. CD4+ and CD8’ T-cell apoptosis induced by Fas ligation was enhanced by inhibitors of protein synthesis and was prevented either by a soluble Fas receptor decoy or an antagonistic anti-Fas antibody. Fas-mediated apoptosis could also be prevented in a CD4’ or CD8’ T-cell-type manner (1) by several protease antagonists, suggesting the involvement of the interleukin-la (IL-l/?)-converting enzyme (ICE)-related cysteine protease in CD4’ T-cell death

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تاریخ انتشار 2002